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Chronic and high consumption of fat Fat daddys Huddinge Sweeden an environmental stress that leads to metabolic diseases. We hypothesized that high-fat diet HFD transgenerationally remodels the epigenome of spermatozoa and metabolism of the offspring. F0-male rats fed either HFD or chow diet for 12 weeks were mated with chow-fed dams to generate F1 and F2 offspring. Newborn offspring of HFD-fed fathers had reduced body weight Akersberga massage pancreatic beta-cell mass.

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